研究生导师朱伟明：中国海洋大学

　　朱伟明，男，1965年2月生，博士、教授、博士生导师，主要从事海洋天然药物研究。已完成主持承担的国家863计划、国家自然科学基金、大洋协会开发计划等国家级研究课题4项，目前主持在研的课题3项。已培养硕士6名、博士1名，协助培养硕士18名、博士9名、博士后1名；在读硕士生8名、博士生6名。已发表学术研究论文112篇，其中SCI收录60篇；申请国家发明专利16项（授权6项）。

　　研究领域 Research field:

　　从海洋微生物资源中发掘创新药物先导化合物To discovery new hits and lead compounds from marine-derived microbes and halotolerant microorganisms by means of integrated screening methods

　　利用生物学与化学相结合的集成筛选方法，从海洋微生物、极端环境微生物中筛选并发现具有重要生物活性的药物先导化合物及药用新资源。

　　中药药理作用的物质基础研究Investigations of pharmacological compounds in the traditional Chinese medicine

　　与药理学家合作，研究传统中药的物质基础，发现其有效成分。

　　天然药物的优化 To discovery new leads by structural modification of new hits<...

　　朱伟明，男，1965年2月生，博士、教授、博士生导师，主要从事海洋天然药物研究。已完成主持承担的国家863计划、国家自然科学基金、大洋协会开发计划等国家级研究课题4项，目前主持在研的课题3项。已培养硕士6名、博士1名，协助培养硕士18名、博士9名、博士后1名；在读硕士生8名、博士生6名。已发表学术研究论文112篇，其中SCI收录60篇；申请国家发明专利16项（授权6项）。

　　研究领域 Research field:

　　从海洋微生物资源中发掘创新药物先导化合物To discovery new hits and lead compounds from marine-derived microbes and halotolerant microorganisms by means of integrated screening methods

　　利用生物学与化学相结合的集成筛选方法，从海洋微生物、极端环境微生物中筛选并发现具有重要生物活性的药物先导化合物及药用新资源。

　　中药药理作用的物质基础研究Investigations of pharmacological compounds in the traditional Chinese medicine

　　与药理学家合作，研究传统中药的物质基础，发现其有效成分。

　　天然药物的优化 To discovery new leads by structural modification of new hits

　　对具有重要生物活性的天然产物进行结构修饰，探讨其构效关系，获得临床候选药物。

　　研究小组成员 Research team:

　　王

　　代表性成果 Selected Publications:

　　1.        Wei-Ming Zhu, Tapping Chemodiversity of Halotolerant Fungal Metabolites for Drug Discovery（邀请报告）, 17th GORDON RESEARCH CONFERENCES on marine natural products, 26 Feb 2008, Ventura California, USA

　　2.        Wenliang Wang, Tianjiao Zhu, Hongwen Tao, Zhenyu Lu, Yuchun Fang, Qianqun Gu, Weiming Zhu, Three Novel, Structurally Unique Spirocyclic Alkaloids from the Halotolerant B-17 Fungus strain of Aspergillus variecolor, Chemistry & Biodiversity 2007, 4(12): 2913-2919.

　　3.        Lin Du, Tianjiao Zhu, Yuchun Fang, Qianqun Gu, and Weiming Zhu, Unusual C25 Steroid Isomers with Bicyclo[4.4.1]A/B Rings from a Volcano Ash-Derived Fungus Penicillium citrinum, J. Nat. Prod. 2008, 71 (8): 1343-1351.

　　4.        Rui Liu, Zhenjian Lin, Tianjiao Zhu, Yuchun Fang, Qianqun Gu, Weiming Zhu, Novel Open-Chain Cytochalsins from the Marine-Derived Fungus Spicaria elegans. J. Nat. Prod. 2008, 71 (7): 1127-1132.

　　5.        Min Zhang, Wen-Liang Wang, Yu-Chun Fang, Tian-Jiao Zhu, Qian-Qun Gu, Wei-Ming Zhu, Cytotoxic Alkaloids and Antibiotic nor-Dammarane Triterpenoids from Marine-Derived Fungus Aspergillus sydowi. J. Nat. Prod. 2008, 71 (6): 985-989.

　　6.        Zhen-Yu Lu, Zhen-Jian Lin, Wen-Liang Wang, Lin Du, Tian-Jiao Zhu, Yu-Chun Fang, Qian-Qun Gu, Wei-Ming Zhu, Citrinin Dimers from the Halotolerant Fungus Penicillium citrinum B-57, J. Nat. Prod. 2008, 71 (4): 543-546.

　　7.        Li Chen, Yuchun Fang, Tianjiao Zhu, Qian-Qun Gu, Wei-Ming Zhu, Nine New Gentisyl Alcohol Derivatives from Marine-derived Fungus Penicillium terrestr...

　　代表性成果 Selected Publications:

　　1. Wei-Ming Zhu, Tapping Chemodiversity of Halotolerant Fungal Metabolites for Drug Discovery（邀请报告）, 17th GORDON RESEARCH CONFERENCES on marine natural products, 26 Feb 2008, Ventura California, USA

　　2. Wenliang Wang, Tianjiao Zhu, Hongwen Tao, Zhenyu Lu, Yuchun Fang, Qianqun Gu, Weiming Zhu, Three Novel, Structurally Unique Spirocyclic Alkaloids from the Halotolerant B-17 Fungus strain of Aspergillus variecolor, Chemistry & Biodiversity 2007, 4(12): 2913-2919.

　　3. Lin Du, Tianjiao Zhu, Yuchun Fang, Qianqun Gu, and Weiming Zhu, Unusual C25 Steroid Isomers with Bicyclo[4.4.1]A/B Rings from a Volcano Ash-Derived Fungus Penicillium citrinum, J. Nat. Prod. 2008, 71 (8): 1343-1351.

　　4. Rui Liu, Zhenjian Lin, Tianjiao Zhu, Yuchun Fang, Qianqun Gu, Weiming Zhu, Novel Open-Chain Cytochalsins from the Marine-Derived Fungus Spicaria elegans. J. Nat. Prod. 2008, 71 (7): 1127-1132.

　　5. Min Zhang, Wen-Liang Wang, Yu-Chun Fang, Tian-Jiao Zhu, Qian-Qun Gu, Wei-Ming Zhu, Cytotoxic Alkaloids and Antibiotic nor-Dammarane Triterpenoids from Marine-Derived Fungus Aspergillus sydowi. J. Nat. Prod. 2008, 71 (6): 985-989.

　　6. Zhen-Yu Lu, Zhen-Jian Lin, Wen-Liang Wang, Lin Du, Tian-Jiao Zhu, Yu-Chun Fang, Qian-Qun Gu, Wei-Ming Zhu, Citrinin Dimers from the Halotolerant Fungus Penicillium citrinum B-57, J. Nat. Prod. 2008, 71 (4): 543-546.

　　7. Li Chen, Yuchun Fang, Tianjiao Zhu, Qian-Qun Gu, Wei-Ming Zhu, Nine New Gentisyl Alcohol Derivatives from Marine-derived Fungus Penicillium terrestre, J. Nat. Prod. 2008, 71 (1): 66-70.

　　8. Fazuo Wang, Yuchun Fang, Tianjiao Zhu, Min Zhang, Aiqun Lin, Qianqun Gu, Weiming Zhu, Seven new prenylated indole diketopiperazine alkaloids from holothurian-derived fungus Aspergillus fumigatus, Tetrahedron 2008, 64(34): 7986-7991.

　　9. Wen-Liang Wang, Zhen-Yu Lu, Hong-Wen Tao, Tian-Jiao Zhu, Yu-Chun Fang, Qian-Qun Gu, Wei-Ming Zhu, Isoechinulin-type Alkaloids, Variecolorin A-L, from Halotolerant Aspergillus variecolor, J. Nat. Prod. 2007, 70 (9): 853-855.

　　10. Zhi Hong Xin, Yuchun Fang, Lin Du, Tianjiao Zhu, Lin Duan, Juan Chen, Qian-Qun Gu, Wei-Ming Zhu, Aurantiomides A-C, Quinazoline Alkaloids from the Sponge- Derived Fungus Penicillium aurantiogriseum SP0-19, J. Nat. Prod. 2007, 70 (5): 853-855.

　　11. Rui Liu, Qianqun Gu, Weiming Zhu, Chengbin Cui, Guotao Fan, Yuchun Fang, Tianjiao Zhu, Hongbing Liu. 10-Phenyl-[12]-cytochalasins Z7, Z8, and Z9 from the marine-derived fungus Spicaria elegans. J. Nat. Prod. 2006, 69(6): 871-875.

　　12. Dehai Li, Fengping Wang, Xiang Xiao, Yuchun Fang, Tianjiao Zhu, Qianqun Gu, Weiming Zhu, Trisorbicillinone A, a novel sorbicillin trimer, from a deep sea fungus, Phialocephala sp. FL30r, Tetrahedron Lett. 2007, 48(30): 5235-5238.

　　13. Yapeng Zhang, Tianjiao Zhu, Yuchun Fang, Hongbing Liu, Qianqun Gu, Weiming Zhu, Carbonarones A and B, New Bioactive gamma-Pyrone and alpha-Pyridone Derivatives from the Marine-derived Fungus Aspergillus carbonarius, J. Antibiot. 2007, 60(2): 153-157.

　　14. Li Chen, Yuchun Fang, Xiaodong Luo, Hongping He, Tianjiao Zhu, Hongbing Liu, Qianqun Gu, Weiming Zhu, Three New Sulfated Alkenes from the Echinus Temnopleurus hardwickii, J. Nat. Prod. 2006, 69 (12): 1787-1789.

　　15. Weizhong Liu, Qianqun Gu, Weiming Zhu, Chengbin Cui, Guotao Fan, Tianjiao Zhu, Hongbing Liu, Yuchun Fang,Penicillones A and B, two novel polyketides with tricyclo [5.3.1.03,8] undecane skeleton, from a marine-derived fungus Penicillium terrestre. Tetrahedron Lett. 2005, 46 (30): 4993-4996.

　　16. Wei Ming Zhu, Chun Hua Lu, Yue Wang, Jun Zhou, Xiao Jiang Hao, Monoterpenoids and Their Glycosides from Winchia calophylla, J. Asian Nat. Prod. Res. 2004, 6 (3): 193