研究生导师曲显俊：山东大学

　　2006年度山东大学校长奖学金

　　2006年度英国皇家学会科研奖励

　　山东省卫生系统第三批中青年重点科技人才1020奖励

　　2006年度山东大学校长奖学金

　　2006年度英国皇家学会科研奖励

　　山东省卫生系统第三批中青年重点科技人才1020奖励

　　[近期主要论著]

　　1.       Yang JL, Qu XJ, Russell PJ, Goldstein D: Regulation of epidermal growth factor receptor in human colon cancer cell lines by interferon-alpha. Gut 2004,53(1): 123-9.

　　2.       Qu XJ, Yang JL, Russell PJ, Goldstein D: Changes in epidermal growth factor receptor expression in human bladder cancer cell lines following interferon-alpha treatment. The Journal of Urology, 2004, 172: 733-738.

　　3.       XIAN-JUN QU, YUN-XIA YUAN, ZHI-GANG TIAN, WEN-FANG XU, MING-HUI CHEN, SHU-XIANG CUI, MASATOSHI MAKUUCHI, MUNEHIRO NAKATA and WEI TANG. Using caffeoyl pyrrolidine derivative LY52, a potential inhibitor of matrix metalloproteinase-2 for suppressing tumor invasion and metastasis， J Inter Molecular Med. 2006, 18(4): 609-14.

　　4.       XIANJUN QU, YUNXIA YUAN, WENFANG XU, MINGHUI CHEN, SHUXIANG CUI, HONG MENG, MASATOSHI MAKUUCHI, MUNEHIRO NAKATA and WEI TANG. Caffeoyl pyrrolidine derivative LY52 inhibits tumor invasion and metastasis via suppressing matrix metalloproteinase activity, Anticancer Res, 26: 5A, 3573-3578, 2006.

　　5.       Xian-jun QU, Shu-xiang CUI, Zhigang TIAN, Xun LI, Ming-hui CHEN, Wen-fang XU, Yoshinori Inagaki, Ying-bing Deng, Masatoshi Makuuchi, Munehiro NAKATA and Wei TANG: Induction of apoptosis in human hepatocellular carcinoma cells by synthetic antineoplaston A10. Anticancer Res, 2007, 27: 2427-2432.

　　6.       Jian Liu, Xun Li, Yan-na Cheng, Shu-xiang Cui, Ming-hui Chen, Wen-fang Xu, Zhi-gang Tian, Masatoshi Makuuchi, Wei Tang a,d, Xian-jun Qu：Inhibition of human gastric carcinoma cell growth by treatment of N3-o-toluyl-fluorouracil as a ...

　　[近期主要论著]

　　1. Yang JL, Qu XJ, Russell PJ, Goldstein D: Regulation of epidermal growth factor receptor in human colon cancer cell lines by interferon-alpha. Gut 2004,53(1): 123-9.

　　2. Qu XJ, Yang JL, Russell PJ, Goldstein D: Changes in epidermal growth factor receptor expression in human bladder cancer cell lines following interferon-alpha treatment. The Journal of Urology, 2004, 172: 733-738.

　　3. XIAN-JUN QU, YUN-XIA YUAN, ZHI-GANG TIAN, WEN-FANG XU, MING-HUI CHEN, SHU-XIANG CUI, MASATOSHI MAKUUCHI, MUNEHIRO NAKATA and WEI TANG. Using caffeoyl pyrrolidine derivative LY52, a potential inhibitor of matrix metalloproteinase-2 for suppressing tumor invasion and metastasis， J Inter Molecular Med. 2006, 18(4): 609-14.

　　4. XIANJUN QU, YUNXIA YUAN, WENFANG XU, MINGHUI CHEN, SHUXIANG CUI, HONG MENG, MASATOSHI MAKUUCHI, MUNEHIRO NAKATA and WEI TANG. Caffeoyl pyrrolidine derivative LY52 inhibits tumor invasion and metastasis via suppressing matrix metalloproteinase activity, Anticancer Res, 26: 5A, 3573-3578, 2006.

　　5. Xian-jun QU, Shu-xiang CUI, Zhigang TIAN, Xun LI, Ming-hui CHEN, Wen-fang XU, Yoshinori Inagaki, Ying-bing Deng, Masatoshi Makuuchi, Munehiro NAKATA and Wei TANG: Induction of apoptosis in human hepatocellular carcinoma cells by synthetic antineoplaston A10. Anticancer Res, 2007, 27: 2427-2432.

　　6. Jian Liu, Xun Li, Yan-na Cheng, Shu-xiang Cui, Ming-hui Chen, Wen-fang Xu, Zhi-gang Tian, Masatoshi Makuuchi, Wei Tang a,d, Xian-jun Qu：Inhibition of human gastric carcinoma cell growth by treatment of N3-o-toluyl-fluorouracil as a precursor of 5-fluorouracil Eur J Pharmacol. 2007; 574(1):1-7.

　　7. Subo Wang, Yanna Cheng, Fengshan Wang, Lirui Sun, Chunhui Liu,

　　Guanjun Chen, Yuhua Li, S.G. Ward, Xianjun Qu：Inhibition activity of sulfated polysaccharide of Sepiella maindroni ink on matrix metalloproteinase (MMP)-2 Biomedicine & Pharmacotherapy (2008) 62(5): 297-302.

　　8. Li-rui Sun, Xun Li, Yan-na Cheng, Hong-yu Yuan, Ming-hui Chen, Wei Tang, Stephen Geoffrey Ward, Xian-jun Qu. Reversal effect of substituted 1,3-dimethyl-1H-quinoxalin-2-ones on multidrug resistance in adriamycin-resistant K562/A02 cells Biomedicine & Pharmacotherapy xx (2008) 1-7.

　　9. Chen MH, Cui SX, Cheng YN, Sun LR, Li QB, Xu WF, Ward SG, Tang W, Qu XJ. Galloyl cyclic-imide derivative CH1104I inhibits tumor invasion through suppressing matrix metalloproteinase activity. Anticancer Drugs. 2008;19(10):957-965.

　　10. Meng Ma, Xian-Jun Qu, Guo-Ying Mu, Ming-Hui Chen, Yan-Na Cheng, Norihiro Kokudo, Wei Tang, Shu- Xiang Cui. Vitamin K2 Inhibits the Growth of Hepatocellular Carcinoma via Decrease of Des-gamma-carboxy Prothrombin. Chemotherapy, 2009; 55:28-35.(DOI:10.1159/000167022).

　　11. Fu-Jun Gao, Shu-Xiang Cui, Ming-Hui Chen, Yan-Na Cheng, Li-Rui Sun, S. G Ward, Norihiro Kokudo, Wei Tang, Xian-Jun Qu: Des-gamma-carboxy prothrombin increases the expression of angiogenic factors in human hepatocellular carcinoma cells. Life Sciences 2008, 83; 815-820.

　　1.     国家自然基金项目“以Pgp为靶点的喹喔啉酮化合物对肿瘤细胞耐药性的逆转作用研究”，首位承担人。时间: 2007-2009年。

　　2.     国家自然基金项目“吡咯烷类MMP抑制剂抗癌作用机制及构效关系研究”，首位承担人，30472038。时间: 2005-2007年。

　　3.       以MMP-2,9为靶点的吡咯烷类化合物抗肿瘤转移作用研究，山东省卫生系统第三中青年重点科技人才资助计划1020。

　　1. 国家自然基金项目“以Pgp为靶点的喹喔啉酮化合物对肿瘤细胞耐药性的逆转作用研究”，首位承担人。时间: 2007-2009年。

　　2. 国家自然基金项目“吡咯烷类MMP抑制剂抗癌作用机制及构效关系研究”，首位承担人，30472038。时间: 2005-2007年。

　　3. 以MMP-2,9为靶点的吡咯烷类化合物抗肿瘤转移作用研究，山东省卫生系统第三中青年重点科技人才资助计划1020。